Fatigue And Mitochondria

Low energy and fatigue are primary complaints familiar to most health coaches and health care providers. In fact, U.S. News & World Report ranks fatigue among the top health complaints. Fatigue that doesn’t go away with rest or sleep is now connected to mitochondrial dysfunction.

If you or your clients are relying on energy drinks or other stimulants to get through the day, the core problem may be at a cellular level.

Health Conditions Related To Mitochondrial Dysfunction

Most, if not all, health conditions can now be directly tied to mitochondrial dysfunction. Studies report a connection with suboptimal mitochondria and cancer, diabetes, fibromyalgia, and serious mental disorders like bipolar and schizophrenia.

Treating symptoms will not be the healthcare of the future. Addressing the root cause or core issues is fast becoming what patients and clients demand. Knowing the science and being able to apply it sets exceptional practitioners and coaches apart from everyone else.

Mitochondrial Blockage

The job of normal functioning mitochondria is to produce and release energy in addition to managing excessive levels of reactive oxygen species (ROS) which could lead to disease and death. A recent study observed that patients with Chronic Fatigue Syndrome showed blockages in the mitochondria.

Much like a clogged sink, these mitochondria were unable to deliver needed energy and remove dangerous toxins.

Decreased Antioxidant Effectiveness

Since mitochondria have their own DNA, or genetic material, they are vulnerable to environmental toxins causing damage to the delicate gene code. If the DNA becomes altered, mitochondrial dysfunction can lead to disease.

An example of this is seen in Chronic Fatigue patients where antioxidant activity is altered, while the presence of ROS (damaging reactive oxygen species) is significantly higher in comparison to healthy adults.

Taking excessive amounts of antioxidants is not the solution, according to research, and in fact, could trigger a cascade of negative events.

How Mitochondria Impact How We Feel

Recent studies have shown that mitochondrial blockages in one area of the body have a profound negative effect on the health of the entire body. Mitochondria release what are known as cytokines, or inflammatory signals, into the bloodstream when they are unable to do their job.

  • Clues to mitochondrial dysfunction
  • The following clues may indicate a core issue related to mitochondrial function:
  • Decreased aerobic capacity
  • Decreased respiratory capacity or feeling “winded” more often with normal workouts
  • Decreased ability to recover after workouts
  • Decreased ability to recover from fatigue after rest
  • General pain or inflammation after working out

Regaining optimal mitochondrial function requires a science based approach. The BX Protocol™ is designed to restore core health and energy.

Association of mitochondrial dysfunction and fatigue: A review of the literature Kristin Filler a,c,⁎, Debra Lyon b, James Bennett d, Nancy McCain a, Ronald Elswick a, Nada Lukkahatai c, Leorey N. Saligan c

a VirginiaCommonwealthUniversitySchoolofNursing,1100EastLeighStreetRichmond,VA23298-0567,USA
b UniversityofFloridaCollegeofNursing,POBox100197,Gainesville,FL32610-0197,USA
c NationalInstitutesofHealth,NationalInstituteofNursingResearch,3CenterDrive,Building3,Room5E26,Bethesda,MD,USA d

VirginiaCommonwealthUniversitySchoolofMedicine,1201EastMarshallStreetRichmond,VA23298-0565,USA Mitochondria: In Sickness and in HealthJodi Nunnari1,* and Anu Suomalainen2,3,* 1Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
2Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, 00290 Helsinki, Finland 3Department of Neurology, Helsinki University Central Hospital, 00290 Helsinki, Finland

*Correspondence: [email protected] (J.N.), [email protected] (A.S.) DOI 10.1016/j.cell.2012.02.035

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